AP24534 (Ponatinib)

Catalog No.: A10080

BCR-ABL inhibitor

AP24534 (Ponatinib)

AP24534 (Ponatinib) Chemical Structure

CAS NO. 943319-70-8

AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$50.00
50 mg
$75.00
100 mg
$100.00
10mM * 1mL in DMSO
$80.00
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  • Yamamoto Y, .et al. Development of a sandwich enzyme-linked immunosorbent assay for the quantification of ponatinib in serum, Anal Biochem, 2019, Feb 13. pii: S0003-2697(18)31083-2 PMID: 30771339
  • N Naganna, .et al. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice, EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755
  • Takuya Hirao, .et al. Altered intracellular signaling by imatinib increases the anti-cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells, Cancer Sci, 2018, Jan; 109(1): 121-131 PMID: 29121435
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Biological Activity

AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.
Targets
Target Value
AblIC50: 0.37nM
PDGFRαIC50: 1.1nM
VEGFR2IC50: 1.5nM
FGFR1IC50: 2.2nM
c-SrcIC50: 5.4nM
c-KitIC50: 12.5nM
Insulin ReceptorIC50: >1μM
IGF-1RIC50: >1μM
AuroraAIC50: >1μM
CDK2/CyclinEIC50: >1μM
In vitro (25°C) DMSO 30 mg/mL (56.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.78 mL 93.88 mL 187.76 mL
0.5 mM 3.76 mL 18.78 mL 37.55 mL
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10080
Actions Inhibitor
M. Wt 532.6
Formula C29H27F3N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 943319-70-8
Synonyms Ponatinib
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

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