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AP24534 (Ponatinib)

Catalog No.: A10080
BCR-ABL inhibitor
Adooq's AP24534 (Ponatinib) has been cited by 6 publications
AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.
AP24534 (Ponatinib)
Grouped product items
Product Name Price Stock Qty
AP24534 10mg
$40.00
In stock
AP24534 25mg
$50.00
In stock
AP24534 50mg
$75.00
In stock
AP24534 100mg
$100.00
In stock
AP24534 (Ponatinib) 10mM * 1mL in DMSO
$80.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's AP24534 (Ponatinib) has been cited by 6 publications
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Yamamoto Y, .et al. , Anal Biochem, 2019, Feb 13. pii: S0003-2697(18)31083-2 PMID: 30771339
  • N Naganna, .et al. , EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755
  • Takuya Hirao, .et al. , Cancer Sci, 2018, Jan; 109(1): 121-131 PMID: 29121435
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
    • Biological Activity
    Discription AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.
    Targets
    Target Value
    Chemical Information
    Catalog Num A10080
    Formula C29H27F3N6O
    Molecular Weight 532.6
    CAS Number 943319-70-8
    SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
    Synonyms Ponatinib
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Solubility
    In vitro (25°C) DMSO 30 mg/mL (56.33 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% CMC Na 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.78 mL 93.88 mL 187.76 mL
    0.5 mM 3.76 mL 18.78 mL 37.55 mL
    1 mM 1.88 mL 9.39 mL 18.78 mL
    5 mM 0.38 mL 1.88 mL 3.76 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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