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APL-1091

Catalog No.: A41542
Drug-linker conjugate for ADC
APL-1091 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It comprises the Mal-Exo-EEVC linker, which facilitates the attachment to antibodies, and MMAE, a potent microtubule inhibitor that disrupts cellular mitosis. This compound is essential for the synthesis of ADCs, enabling targeted delivery of cytotoxic agents to cancer cells, thereby enhancing therapeutic efficacy while minimizing off-target effects.
APL-1091 2921735-87-5 Drug-linker conjugate for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAPL-1091 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It comprises the Mal-Exo-EEVC linker, which facilitates the attachment to antibodies, and MMAE, a potent microtubule inhibitor that disrupts cellular mitosis. This compound is essential for the synthesis of ADCs, enabling targeted delivery of cytotoxic agents to cancer cells, thereby enhancing therapeutic efficacy while minimizing off-target effects.
Product Information
Catalog NumA41542
FormulaC80H122N14O22
Molecular Weight1631.91
CAS Number2921735-87-5
SMILESO[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OC(C3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O)C(NCCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)OC)=O
SynonymsMal-Exo-EEVC-MMAE
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC