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- Wang L, .et al. Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function, J Am Chem Soc, 2019, Aug 14;141(32):12673-12681 PMID: 31381313
- Koide H, .et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 PMID: 29034773
Biological Activity
ARQ-197 is a selective inhibitor of the c-Met receptor tyrosine kinase
| In vitro | DMSO | 69 mg/mL (186.77 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.07 mL | 135.35 mL | 270.71 mL |
| 0.5 mM | 5.41 mL | 27.07 mL | 54.14 mL |
| 1 mM | 2.71 mL | 13.54 mL | 27.07 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.41 mL |
*The above data is based on the productmolecular weight 369.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11087 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1000873-98-2, 905854-02-6 |
| Formula | C23H19N3O2 |
| M. Wt | 369.4 |
| Purity | >98% |
| Synonyms | ARQ197 |
| SMILES | C1CC2=CC=CC3=C2N(C1)C=C3[C@H]4[C@@H](C(=O)NC4=O)C5=CNC6=CC=CC=C65 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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