Asciminib-NH2

Catalog No.: A33629
BCR-ABL Ligand
Asciminib-NH2 is a ligand targeting BCR-ABL, specifically involved in the modulation of oncogenic signaling pathways. This compound is crucial for the synthesis of proteolysis-targeting chimeras (PROTACs), including P19As, facilitating the targeted degradation of BCR-ABL fusion proteins. Its utility in research supports investigations into targeted cancer therapies and the mechanistic study of BCR-ABL related malignancies.
Grouped product items
Size Stock
5mg
10mg
50mg
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

Loading distributor info...

Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAsciminib-NH2 is a ligand targeting BCR-ABL, specifically involved in the modulation of oncogenic signaling pathways. This compound is crucial for the synthesis of proteolysis-targeting chimeras (PROTACs), including P19As, facilitating the targeted degradation of BCR-ABL fusion proteins. Its utility in research supports investigations into targeted cancer therapies and the mechanistic study of BCR-ABL related malignancies.
Product Information
Catalog NumA33629
FormulaC20H19ClF2N6O2
Molecular Weight448.85
CAS Number3106065-83-9
SMILESN[C@@H]1CCN(C2=NC=C(C(NC3=CC=C(OC(Cl)(F)F)C=C3)=O)C=C2C4=NNC=C4)C1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2