AT101 acetic acid

Catalog No.: A13578

pan Bcl-2 inhibitor

AT101 acetic acid Chemical Structure

CAS NO. 866541-93-7

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID

Availability: In stock

Package Price Qty
10 mg
$100.00
25 mg
$200.00
50 mg
$350.00
100 mg
$600.00
10mM * 1mL in DMSO
$117.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID
Targets
Mcl-1 (Cell-free assay) Bcl-2 (Cell-free assay) Bcl-xL (Cell-free assay)
0.18 μM(Ki)0.32 μM(Ki)0.48 μM(Ki)
In vitro (25°C) DMSO 116 mg/mL (200.48 mM)
Water <1 mg/mL (<1 mM)
Ethanol 89 mg/mL (153.81 mM)
In vivo 0.5% CMC 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.28 mL 86.41 mL 172.83 mL
0.5 mM 3.46 mL 17.28 mL 34.57 mL
1 mM 1.73 mL 8.64 mL 17.28 mL
5 mM 0.35 mL 1.73 mL 3.46 mL

*The above data is based on the productmolecular weight 578.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13578
Actions Inhibitor
M. Wt 578.61
Formula C30H30O8.C2H4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 866541-93-7
Synonyms AT-101, AT 101
SMILES CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C.CC(=O)O

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