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AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID
Targets
| Mcl-1 (Cell-free assay) | Bcl-2 (Cell-free assay) | Bcl-xL (Cell-free assay) | ||
| 0.18 μM(Ki) | 0.32 μM(Ki) | 0.48 μM(Ki) |
| In vitro (25°C) | DMSO | 108 mg/mL (186.65 mM) | |
| Water | Insoluble | ||
| Ethanol | 83 mg/mL | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.28 mL | 86.41 mL | 172.83 mL |
| 0.5 mM | 3.46 mL | 17.28 mL | 34.57 mL |
| 1 mM | 1.73 mL | 8.64 mL | 17.28 mL |
| 5 mM | 0.35 mL | 1.73 mL | 3.46 mL |
*The above data is based on the productmolecular weight 578.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13578 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 866541-93-7 |
| Formula | C30H30O8.C2H4O2 |
| M. Wt | 578.61 |
| Purity | >98% |
| Synonyms | AT-101, AT 101 |
| SMILES | CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C.CC(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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