Atibuclimab is a chimeric monoclonal antibody targeting CD14, comprised of murine variable regions and human IgG4 Fc regions. This antibody is specifically designed for research purposes in amyotrophic lateral sclerosis (ALS). Atibuclimab effectively moderates lipopolysaccharide (LPS)-induced symptoms and robustly suppresses the release of proinflammatory cytokines induced by LPS. Concurrently, it moderately delays the secretion of anti-inflammatory cytokines, including soluble TNF receptor type I and IL-1 receptor antagonist, providing a distinct profile of cytokine regulation. This dual action makes Atibuclimab a valuable tool for investigating inflammatory pathways and their modulation in ALS research.
Atibuclimab is a chimeric monoclonal antibody targeting CD14, comprised of murine variable regions and human IgG4 Fc regions. This antibody is specifically designed for research purposes in amyotrophic lateral sclerosis (ALS). Atibuclimab effectively moderates lipopolysaccharide (LPS)-induced symptoms and robustly suppresses the release of proinflammatory cytokines induced by LPS. Concurrently, it moderately delays the secretion of anti-inflammatory cytokines, including soluble TNF receptor type I and IL-1 receptor antagonist, providing a distinct profile of cytokine regulation. This dual action makes Atibuclimab a valuable tool for investigating inflammatory pathways and their modulation in ALS research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
