Auristatin S

Catalog No.: A41096
ADC Payload
Auristatin S is a potent antitumor agent designed as a payload for antibody-drug conjugates (ADCs). It exhibits significant cytotoxic activity while mitigating bystander effects and enhancing off-target toxicity profiles. Auristatin S demonstrates excellent tolerability in Karpas and KarpasBVR cell models, making it a valuable tool for targeted cancer therapies across various tumor types. Its unique properties support its application in the development of effective ADCs for cancer treatment research.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAuristatin S is a potent antitumor agent designed as a payload for antibody-drug conjugates (ADCs). It exhibits significant cytotoxic activity while mitigating bystander effects and enhancing off-target toxicity profiles. Auristatin S demonstrates excellent tolerability in Karpas and KarpasBVR cell models, making it a valuable tool for targeted cancer therapies across various tumor types. Its unique properties support its application in the development of effective ADCs for cancer treatment research.
Product Information
Catalog NumA41096
FormulaC38H65N5O8
Molecular Weight719.95
CAS Number3028453-70-2
SMILESCC[C@@H]([C@H](N(C([C@H](C(C)C)NC([C@H](CO)N(C)C)=O)=O)C)[C@H](OC)CC(N1CCC[C@H]1[C@@H]([C@@H](C)C(N[C@@H](CC2=CC=CC=C2)CO)=O)OC)=O)C
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