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AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM, >1400-fold selectivity over the other kinases assayed.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.19 mL | 85.97 mL | 171.93 mL |
| 0.5 mM | 3.44 mL | 17.19 mL | 34.39 mL |
| 1 mM | 1.72 mL | 8.6 mL | 17.19 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 581.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15008 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 581.62 |
| Formula | C28H28FN5O6S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1360053-81-1 |
| Synonyms | AVL292 benzenesulfonate, AVL 292 benzenesulfonate |
| SMILES | COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F.C1=CC=C(C=C1)S(=O)(=O)O |
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