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AZD-5904 is a potent orally bioavailable MPO inhibitor. In preclinical studies, AZD-5904 inhibited the isolated MPO enzyme with an IC50 of 140 nM and was approximately equipotent in assays of rat and mouse MPO enzyme activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 39.64 mL | 198.18 mL | 396.37 mL |
| 0.5 mM | 7.93 mL | 39.64 mL | 79.27 mL |
| 1 mM | 3.96 mL | 19.82 mL | 39.64 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.93 mL |
*The above data is based on the productmolecular weight 252.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17062 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 252.29 |
| Formula | C10H12N4O2S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 618913-30-7 |
| Synonyms | AZ1, AZ 1 AZ-1, TX4, TX-4, TX 4, AZD 5904, AZD5904 |
| SMILES | O=C1NC(N(C[[email protected]]2OCCC2)C3=C1NC=N3)=S |
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