Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order


Catalog No.: A11075

FGFR inhibitor


AZD4547 Chemical Structure

CAS NO. 1035270-39-3

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.

Availability: In stock

Package Price Qty
5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Ryuma Tokunaga, .et al. Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma, Oncotarget, 2016, Apr 12; 7(15): 19748-19761 PMID: 26933914
  • Mitsuko Kawano, .et al. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling, Adv Radiat Oncol, 2016, Jul-Sep; 1(3): 170-181 PMID: 28740887

Biological Activity

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.
Target Value
FGFR1IC50: 0.2nM
FGFR3IC50: 1.8nM
FGFR2IC50: 2.5nM
KDRIC50: 24nM
FGFR4IC50: 165nM
IGFRIC50: 581nM
AxlIC50: >2μM
CDK2IC50: >10μM
FAKIC50: >10μM
ROCK2IC50: >50μM
Akt1IC50: >100μM
ALK1IC50: >100μM
p38IC50: >100μM
PI3KαIC50: >100μM
In vitro (25°C) DMSO 79 mg/mL (170.41 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.57 mL 107.85 mL 215.7 mL
0.5 mM 4.31 mL 21.57 mL 43.14 mL
1 mM 2.16 mL 10.79 mL 21.57 mL
5 mM 0.43 mL 2.16 mL 4.31 mL

*The above data is based on the productmolecular weight 463.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11075
Actions Inhibitor
CAS No. 1035270-39-3
Formula C26H33N5O3
M. Wt 463.6
Purity >98%
Synonyms AZD-4547
SMILES C[[email protected]@H]1CN(C[[email protected]@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy AZD4547 | AZD4547 Supplier | purchase | cost | manufacturer | order | distributor | buy 1035270-39-3| 1035270-39-3 Supplier | purchase 1035270-39-3 | 1035270-39-3 cost | 1035270-39-3 manufacturer | order 1035270-39-3 | 1035270-39-3 distributor