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- Ryuma Tokunaga, .et al. Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma, Oncotarget, 2016, Apr 12; 7(15): 19748-19761 PMID: 26933914
- Mitsuko Kawano, .et al. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling, Adv Radiat Oncol, 2016, Jul-Sep; 1(3): 170-181 PMID: 28740887
Biological Activity
AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.
Targets
Target | Value |
---|---|
FGFR1 | IC50: 0.2nM |
FGFR3 | IC50: 1.8nM |
FGFR2 | IC50: 2.5nM |
KDR | IC50: 24nM |
FGFR4 | IC50: 165nM |
IGFR | IC50: 581nM |
Axl | IC50: >2μM |
CDK2 | IC50: >10μM |
FAK | IC50: >10μM |
ROCK2 | IC50: >50μM |
Akt1 | IC50: >100μM |
ALK1 | IC50: >100μM |
p38 | IC50: >100μM |
PI3Kα | IC50: >100μM |
In vitro (25°C) | DMSO | 79 mg/mL (170.41 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 4% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.57 mL | 107.85 mL | 215.7 mL |
0.5 mM | 4.31 mL | 21.57 mL | 43.14 mL |
1 mM | 2.16 mL | 10.79 mL | 21.57 mL |
5 mM | 0.43 mL | 2.16 mL | 4.31 mL |
*The above data is based on the productmolecular weight 463.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11075 |
---|---|
Actions | Inhibitor |
CAS No. | 1035270-39-3 |
Formula | C26H33N5O3 |
M. Wt | 463.6 |
Purity | >98% |
Synonyms | AZD-4547 |
SMILES | C[[email protected]@H]1CN(C[[email protected]@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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