AZD4547

Name: AZD4547
Brand: Adooq Bioscience
SKU: A11075
Rating: 100 (2 reviews)

Catalog No.: A11075

FGFR inhibitor

Product Citations (2)

AZD4547 Chemical Structure

CAS NO. 1035270-39-3

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$70.00
50 mg	$140.00
100 mg	$190.00
10mM * 1mL in DMSO	$55.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq AZD4547

Ryuma Tokunaga, .et al. Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma, Oncotarget, 2016, Apr 12; 7(15): 19748-19761 PMID: 26933914
Mitsuko Kawano, .et al. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling, Adv Radiat Oncol, 2016, Jul-Sep; 1(3): 170-181 PMID: 28740887

Biological Activity

AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.

Targets

Target	Value
FGFR1	IC50: 0.2nM
FGFR3	IC50: 1.8nM
FGFR2	IC50: 2.5nM
KDR	IC50: 24nM
FGFR4	IC50: 165nM
IGFR	IC50: 581nM
Axl	IC50: >2μM
CDK2	IC50: >10μM
FAK	IC50: >10μM
ROCK2	IC50: >50μM
Akt1	IC50: >100μM
ALK1	IC50: >100μM
p38	IC50: >100μM
PI3Kα	IC50: >100μM

Solubility *

In vitro (25°C)	DMSO	79 mg/mL (170.41 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.57 mL	107.85 mL	215.7 mL
0.5 mM	4.31 mL	21.57 mL	43.14 mL
1 mM	2.16 mL	10.79 mL	21.57 mL
5 mM	0.43 mL	2.16 mL	4.31 mL

*The above data is based on the productmolecular weight 463.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11075
Actions	Inhibitor
CAS No.	1035270-39-3
Formula	C26H33N5O3
M. Wt	463.6
Purity	>98%
Synonyms	AZD-4547
SMILES	C[[email protected]@H]1CN(C[[email protected]@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.