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Biological Activity
AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.88 mL | 74.38 mL | 148.75 mL |
| 0.5 mM | 2.98 mL | 14.88 mL | 29.75 mL |
| 1 mM | 1.49 mL | 7.44 mL | 14.88 mL |
| 5 mM | 0.3 mL | 1.49 mL | 2.98 mL |
*The above data is based on the productmolecular weight 672.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16880 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2143061-81-6 |
| Formula | C35H34ClN5O3S2 |
| M. Wt | 672.25 |
| Purity | >98% |
| Synonyms | AZD-5991, AZD 5991 |
| SMILES | O=C(O)C1=C(CCCOC2=C(C=CC=C3)C3=CC4=C2)C5=C(N1C)C(C6=C(C)N(C)N=C6CSCC7=NN(C)C(CS4)=C7)=C(Cl)C=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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