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Azido-PEG4-Val-Cit-PAB-MMAE

Catalog No.: A41411
Drug-Linker Conjugates for ADC
Azido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It incorporates the potent anti-mitotic agent, monomethyl auristatin E (MMAE), via a cleavable linker that facilitates targeted delivery. This reagent features an azide group and is suitable for click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules, as well as DBCO or BCN groups. Its use in ADC development underscores its significance in research focused on targeted cancer therapies.
Azido-PEG4-Val-Cit-PAB-MMAE 1869126-64-6 Drug-Linker Conjugates for ADC
Grouped product items
Size Price Stock Qty
1mg
$290.00
In stock
5mg
$715.00
In stock
10mg
$1,075.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAzido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It incorporates the potent anti-mitotic agent, monomethyl auristatin E (MMAE), via a cleavable linker that facilitates targeted delivery. This reagent features an azide group and is suitable for click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules, as well as DBCO or BCN groups. Its use in ADC development underscores its significance in research focused on targeted cancer therapies.
Product Information
Catalog NumA41411
FormulaC69H113N13O17
Molecular Weight1396.71
CAS Number1869126-64-6
SMILESO[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC