- Takino JI, .et al. The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells, Sci Rep, 2019, Nov 13;9(1):16717 PMID: 31723205
Biological Activity
BAM 7 binds the BAX trigger site with an EC50 ~ 3.3 μM as measured in a competitive FP assay using FITC-BIM SAHB and BAX.
Targets
Bax | ||||
3.3 μM(EC50) |
In vitro | DMSO | 2 mg/mL (4.93 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.66 mL | 123.31 mL | 246.63 mL |
0.5 mM | 4.93 mL | 24.66 mL | 49.33 mL |
1 mM | 2.47 mL | 12.33 mL | 24.66 mL |
5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
*The above data is based on the productmolecular weight 405.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A12907 |
---|---|
Actions | Activator |
M. Wt | 405.47 |
Formula | C21H19N5O2S |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 331244-89-4 |
Synonyms | BAM7 |
SMILES | CCOC1=CC=CC=C1N/N=C/2\C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C |
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