BAY 61-3606 hydrochloride is a highly selective Syk inhibitor that acts in an ATP-competitive manner with a Ki of 7.5 nM and an IC50 of 10 nM. It effectively reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells and significantly decreases Syk phosphorylation in K-rn cell lysates. Additionally, BAY 61-3606 hydrochloride enhances TRAIL-induced apoptosis in breast cancer cells by downregulating Mcl-1, making it a valuable tool for investigating Syk-related pathways in cancer research.
BAY 61-3606 hydrochloride is a highly selective Syk inhibitor that acts in an ATP-competitive manner with a Ki of 7.5 nM and an IC50 of 10 nM. It effectively reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells and significantly decreases Syk phosphorylation in K-rn cell lysates. Additionally, BAY 61-3606 hydrochloride enhances TRAIL-induced apoptosis in breast cancer cells by downregulating Mcl-1, making it a valuable tool for investigating Syk-related pathways in cancer research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
