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Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.3 mL | 166.5 mL | 333 mL |
| 0.5 mM | 6.66 mL | 33.3 mL | 66.6 mL |
| 1 mM | 3.33 mL | 16.65 mL | 33.3 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
*The above data is based on the productmolecular weight 300.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A13580 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 300.3 |
| Formula | C16H16N2O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 383860-03-5 |
| Synonyms | TW-37 |
| SMILES | COC1=CC(=C(C=C1)N=O)CCC2=C(C=CC(=C2)OC)N=O |
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