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Publications citing Adooq Products
Bcl-2 Inhibitor Citations (1)
- Toshiyuki Sumi,et al. Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas, Int J Oncol, 2018, Jul; 53(1): 33-46 29658609
Chemical Information
| Catalog Num | A13580 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 300.3 |
| Formula | C16H16N2O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 383860-03-5 |
| Synonyms | TW-37 |
| SMILES code | COC1=CC(=C(C=C1)N=O)CCC2=C(C=CC(=C2)OC)N=O |
| Chemical Name | N-[4-[[2-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]PHENYL]-2,3,4-TRIHYDROXY-5-[[2-(1-METHYLETHYL)PHENYL]METHYL]BENZAMIDE |
Description |
Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively). | |||||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.3 mL | 166.5 mL | 333mL |
| 0.5 mM | 6.66 mL | 33.3 mL | 66.6 mL |
| 1 mM | 3.33 mL | 16.65 mL | 33.3 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
*The above data is based on the productmolecular weight 300.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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