BLU9931

Name: BLU9931
Brand: Adooq Bioscience
SKU: A15534
Rating: 100 (268 reviews)

Catalog No.: A15534

FGFR inhibitor

BLU9931 Chemical Structure

CAS NO. 1538604-68-0

BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM),

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$85.00
25 mg	$150.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Biological Activity

BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM),

Targets

FGFR4	FGFR3	FGFR2	FGFR1
3 nM	150 nM	493 nM	591 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 4 mg/mL (7.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% carboxymethylcellulose+1% Tween 80 as a suspension	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.63 mL	98.16 mL	196.32 mL
0.5 mM	3.93 mL	19.63 mL	39.26 mL
1 mM	1.96 mL	9.82 mL	19.63 mL
5 mM	0.39 mL	1.96 mL	3.93 mL

*The above data is based on the productmolecular weight 509.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A15534
Actions	Inhibitor
CAS No.	1538604-68-0
Formula	C26H22Cl2N4O3
M. Wt	509.38
Purity	>98%
Synonyms	BLU-9931, BLU 9931
SMILES	CC1=C(C(=CC=C1)NC(=O)C=C)NC2=NC=C3C=C(C=CC3=N2)C4=C(C(=CC(=C4Cl)OC)OC)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.