BLZ945

Catalog No.: A15540

CSF1R inhibitor

BLZ945

BLZ945 Chemical Structure

CAS NO. 953769-46-5

BLZ945 is a potent and selective CSF-1R kinase inhibitor. It attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas.

Availability: In stock

Package Price Qty
10 mg
$125.00
25 mg
$220.00
50 mg
$300.00
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Biological Activity

BLZ945 is a potent and selective CSF-1R kinase inhibitor. It attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas.
Targets
CSF-1R
1 nM
In vitro (25°C) DMSO 77 mg/mL (193.23 mM)
Water Insoluble
Ethanol Warmed: 3 mg/mL
In vivo 4% DMSO+30% PEG 300+ddH2O 2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.1 mL 125.5 mL 251 mL
0.5 mM 5.02 mL 25.1 mL 50.2 mL
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL

*The above data is based on the productmolecular weight 398.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15540
Actions Inhibitor
CAS No. 953769-46-5
Formula C20H22N4O3S
M. Wt 398.4
Solubility DMSO
Purity >98%
Synonyms BLZ 945, BLZ-945
SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC4CCCCC4O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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