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Biological Activity
BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.38 mL | 46.92 mL | 93.84 mL |
| 0.5 mM | 1.88 mL | 9.38 mL | 18.77 mL |
| 1 mM | 0.94 mL | 4.69 mL | 9.38 mL |
| 5 mM | 0.19 mL | 0.94 mL | 1.88 mL |
*The above data is based on the productmolecular weight 1065.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18387 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1391107-54-2 |
| Formula | C52H56ClF3N6O7S3 |
| M. Wt | 1065.68 |
| Purity | >98% |
| Synonyms | BM957, BM-957 |
| SMILES | O=C(C1=C(C)N(CC)C(C2=CC=C(Cl)C=C2)=C1C3=CC=CC(N4CCN(C5=CC=C(NS(=O)(C6=CC=C(N[C@H](CCN7CCC(O)CC7)CSC8=CC=CC=C8)C(S(=O)(C(F)(F)F)=O)=C6)=O)C=C5)CC4)=C3)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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