BMS-986143 is a potent, orally active inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 0.26 nM, demonstrating significant selectivity against a range of kinases. This compound also inhibits TEC, BLK, BMX, TXK, FGR, YES1, and ITK with varying IC50 values, establishing its broad-spectrum activity. BMS-986143 is valuable for research into autoimmune diseases, providing insights into the modulation of B cell signaling and function.
BMS-986143 is a potent, orally active inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 0.26 nM, demonstrating significant selectivity against a range of kinases. This compound also inhibits TEC, BLK, BMX, TXK, FGR, YES1, and ITK with varying IC50 values, establishing its broad-spectrum activity. BMS-986143 is valuable for research into autoimmune diseases, providing insights into the modulation of B cell signaling and function.
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