BPR5K230 is a dual inhibitor targeting the receptor tyrosine kinases MER and AXL, exhibiting IC50 values of 4.1 nM and 9.2 nM, respectively. This compound effectively inhibits the proliferation of Ba/F3-MER cells, with an IC50 of 5 nM. In preclinical models, BPR5K230 demonstrates anti-inflammatory and antitumor activities against various cancer cell lines, including 4T1, MDA-MB-231, MC38, and Hepa1-6, as well as favorable pharmacokinetic properties in mice. These attributes make BPR5K230 a valuable tool for research into cancer biology and targeted therapies.
BPR5K230 is a dual inhibitor targeting the receptor tyrosine kinases MER and AXL, exhibiting IC50 values of 4.1 nM and 9.2 nM, respectively. This compound effectively inhibits the proliferation of Ba/F3-MER cells, with an IC50 of 5 nM. In preclinical models, BPR5K230 demonstrates anti-inflammatory and antitumor activities against various cancer cell lines, including 4T1, MDA-MB-231, MC38, and Hepa1-6, as well as favorable pharmacokinetic properties in mice. These attributes make BPR5K230 a valuable tool for research into cancer biology and targeted therapies.
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