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BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
| In vitro | DMSO | 77 mg/mL (178.85 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.23 mL | 116.14 mL | 232.28 mL |
| 0.5 mM | 4.65 mL | 23.23 mL | 46.46 mL |
| 1 mM | 2.32 mL | 11.61 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
*The above data is based on the productmolecular weight 430.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16835 |
|---|---|
| Actions | Modulator |
| CAS No. | 314761-14-3 |
| Formula | C21H14N6OS2 |
| M. Wt | 430.51 |
| Purity | >98% |
| SMILES | O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C4=CC=CC=C4)C3=N\NC5=NC=CS5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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