c-Met-IN-12 is a potent and selective type II c-Met kinase inhibitor, exhibiting an IC50 of 10.6 nM. This compound effectively inhibits c-Met as well as AXL, Mer, and TYRO3 kinases, demonstrating an inhibition rate exceeding 80% at 1 μM concentration. c-Met-IN-12 shows promising antitumor efficacy and serves as a valuable scaffold for the development of further kinase selectivity enhancements in cancer research applications.
c-Met-IN-12 is a potent and selective type II c-Met kinase inhibitor, exhibiting an IC50 of 10.6 nM. This compound effectively inhibits c-Met as well as AXL, Mer, and TYRO3 kinases, demonstrating an inhibition rate exceeding 80% at 1 μM concentration. c-Met-IN-12 shows promising antitumor efficacy and serves as a valuable scaffold for the development of further kinase selectivity enhancements in cancer research applications.
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