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Cediranib (AZD2171)

Catalog No.: A10185

VEGFR inhibitor

Cediranib (AZD2171)

Cediranib (AZD2171) Chemical Structure

CAS NO. 288383-20-0

Cediranib (AZD2171) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
  • Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298

Biological Activity

Cediranib (AZD2171) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.
Target Value
c-KitIC50: 2nM
VEGFR3/FLT4IC50: <=3nM
FGFR1IC50: 26nM
PDGFRαIC50: 36nM
CSF-1RIC50: 110nM
SrcIC50: 130nM
AblIC50: 260nM
FLT3IC50: >1μM
HER2/ErbB2IC50: >1μM
CDK2IC50: >1μM
CDK4IC50: >1μM
EGFRIC50: 1.6μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
MEKIC50: >10μM
In vitro (25°C) DMSO 80 mg/mL (177.57 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+50% PEG 300+5% Tween+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.2 mL 110.99 mL 221.98 mL
0.5 mM 4.44 mL 22.2 mL 44.4 mL
1 mM 2.22 mL 11.1 mL 22.2 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10185
Actions Inhibitor
CAS No. 288383-20-0
Formula C25H27FN4O3
M. Wt 450.5
Purity >98%
Synonyms Recentin

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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