cis VH-298 is a VHL:HIF-α interaction inhibitor that disrupts the binding of hydroxylated HIF-1α peptides to the VHL complex. This compound demonstrates a significant loss of binding specificity, making it a valuable tool for investigating the hypoxia response pathway. Its applications extend to studies in cancer research, where modulation of HIF signaling is critical.
cis VH-298 is a VHL:HIF-α interaction inhibitor that disrupts the binding of hydroxylated HIF-1α peptides to the VHL complex. This compound demonstrates a significant loss of binding specificity, making it a valuable tool for investigating the hypoxia response pathway. Its applications extend to studies in cancer research, where modulation of HIF signaling is critical.
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