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CL2E-SN38

Catalog No.: A41564
Drug-Linker Conjugates for ADC
CL2E-SN38 is a potent drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound features SN-38, the active metabolite of Irinotecan, which acts as a Topoisomerase I inhibitor, disrupting DNA replication and transcription. Given its high release potential and structural stability, CL2E-SN38 is suitable for advanced cancer therapeutics research and the development of targeted treatments with reduced systemic toxicity.
CL2E-SN38 1639139-65-3 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCL2E-SN38 is a potent drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound features SN-38, the active metabolite of Irinotecan, which acts as a Topoisomerase I inhibitor, disrupting DNA replication and transcription. Given its high release potential and structural stability, CL2E-SN38 is suitable for advanced cancer therapeutics research and the development of targeted treatments with reduced systemic toxicity.
Product Information
Catalog NumA41564
FormulaC87H116N14O24
Molecular Weight1741.93
CAS Number1639139-65-3
SMILESO=C1N(C2)C(C(C2=C(C3=C4)CC)=NC3=CC=C4OC(N(C)CCN(C)C(OCC(C=C5)=CC=C5NC([C@H](CCCCN)NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN(N=N6)C=C6CNC(C(CC7)CCC7CN(C8=O)C(C=C8)=O)=O)=O)=O)CC9=CC=CC=C9)=O)=O)=O)=O)=CC([C@](O)%10CC)=C1COC%10=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC