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PDGFRα/β inhibitor

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Catalog No. A11350

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CP-673451 5mg A11350-5

Regular Price: $120.00

Special Price: $108.00

CP-673451 10mg A11350-10

Regular Price: $200.00

Special Price: $180.00

CP-673451 25mg A11350-25

Regular Price: $380.00

Special Price: $342.00

CP-673451 50mg A11350-50

Regular Price: $680.00

Special Price: $612.00

CP-673451 10mM * 1mL in DMSO A11350-10mM-D

Regular Price: $159.00

Special Price: $143.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.


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Publications citing Adooq Products
CP-673451 Citations (1)
  • Kaori Aoto, .et al. Complex formation between platelet-derived growth factor receptor β and transforming growth factor β receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts, Oncotarget, 2018, Sep 25; 9(75): 34090-34102 PMID: 30344924

Chemical Information

Catalog Num A11350
Actions Inhibitor
M. Wt 417.5
Formula C24H27N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 343787-29-1
Synonyms CP673451

Biological Activity

CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.
Target Value
PDGFRαIC50: 10nM
c-KitIC50: 252nM
VEGFR1IC50: 450nM
VEGFR2IC50: 450nM
LCKIC50: >1μM
SrcIC50: >2μM
v-AblIC50: >5μM
Tie-2IC50: >5μM
bFGFRIC50: >5μM
EGFRIC50: >10μM
ErbB2IC50: >10μM
c-MetIC50: >10μM
IGF-1RIC50: >10μM


Solubility (25°C)* In vitro DMSO 28 mg/mL heating (67.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (9.58 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.95 mL 119.76 mL 239.52mL
0.5 mM 4.79 mL 23.95 mL 47.9 mL
1 mM 2.4 mL 11.98 mL 23.95 mL
5 mM 0.48 mL 2.4 mL 4.79 mL

*The above data is based on the productmolecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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