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- Kaori Aoto, .et al. Complex formation between platelet-derived growth factor receptor β and transforming growth factor β receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts, Oncotarget, 2018, Sep 25; 9(75): 34090-34102 PMID: 30344924
Biological Activity
CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.
Targets
| Target | Value |
|---|---|
| PDGFRβ | IC50: 1nM |
| PDGFRα | IC50: 10nM |
| c-Kit | IC50: 252nM |
| VEGFR1 | IC50: 450nM |
| VEGFR2 | IC50: 450nM |
| LCK | IC50: >1μM |
| Src | IC50: >2μM |
| v-Abl | IC50: >5μM |
| Tie-2 | IC50: >5μM |
| bFGFR | IC50: >5μM |
| EGFR | IC50: >10μM |
| ErbB2 | IC50: >10μM |
| c-Met | IC50: >10μM |
| IGF-1R | IC50: >10μM |
| In vitro (25°C) | DMSO | Warmed: 28 mg/mL (67.06 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 2.3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.95 mL | 119.76 mL | 239.52 mL |
| 0.5 mM | 4.79 mL | 23.95 mL | 47.9 mL |
| 1 mM | 2.4 mL | 11.98 mL | 23.95 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.79 mL |
*The above data is based on the productmolecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11350 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 343787-29-1 |
| Formula | C24H27N5O2 |
| M. Wt | 417.5 |
| Purity | >98% |
| Synonyms | CP673451 |
| SMILES | COCCOC1=CC2=C(C=C1)N(C=N2)C3=NC4=C(C=CC=C4N5CCC(CC5)N)C=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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