CSF1R-IN-5

Catalog No.: A34619
CSF1R Inhibitor
CSF1R-IN-5 is a potent inhibitor of the colony-stimulating factor 1 receptor (CSF1R), which plays a critical role in the survival and differentiation of macrophages. By targeting the CSF-1/CSF-1R signaling pathway, CSF1R-IN-5 modulates the interaction between tumor-associated macrophages (TAMs) and glioma cells, influencing the exchange of inflammatory mediators. This compound is useful for research applications in cancer biology, particularly in studies investigating the tumor microenvironment and macrophage function in oncogenesis.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCSF1R-IN-5 is a potent inhibitor of the colony-stimulating factor 1 receptor (CSF1R), which plays a critical role in the survival and differentiation of macrophages. By targeting the CSF-1/CSF-1R signaling pathway, CSF1R-IN-5 modulates the interaction between tumor-associated macrophages (TAMs) and glioma cells, influencing the exchange of inflammatory mediators. This compound is useful for research applications in cancer biology, particularly in studies investigating the tumor microenvironment and macrophage function in oncogenesis.
Product Information
Catalog NumA34619
FormulaC22H19N7O3
Molecular Weight429.43
CAS Number2716184-93-7
SMILESO=C(C1=CN=C2N(CCC2)C1=O)NC3=NC=C(C=C3)OC4=CC=NC(C5=CN(C)N=C5)=C4
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