CXF-009

Catalog No.: A33545
FGFR4 Inhibitor
CXF-009 is a selective and covalent inhibitor of FGFR4, demonstrating an IC50 of 48 nM. By targeting cysteine residues Cys477 and Cys552, CXF-009 effectively modulates FGFR4 activity. This compound is suitable for research applications related to hepatocellular carcinoma, facilitating investigations into FGFR4's role in cancer biology.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCXF-009 is a selective and covalent inhibitor of FGFR4, demonstrating an IC50 of 48 nM. By targeting cysteine residues Cys477 and Cys552, CXF-009 effectively modulates FGFR4 activity. This compound is suitable for research applications related to hepatocellular carcinoma, facilitating investigations into FGFR4's role in cancer biology.
Product Information
Catalog NumA33545
FormulaC33H38N8O5
Molecular Weight626.71
CAS Number2727084-00-4
SMILESO=C(NC1=C(NC2=NC=C3C(N(CCCN4CCN(CC4)C(C=C)=O)C(N(C3)C5=CC(OC)=CC(OC)=C5)=O)=N2)C=CC=C1)C=C
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