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Cys-MC-VC-PAB-MMAE

Catalog No.: A41424
Drug-Linker Conjugates for ADC
Cys-MC-VC-PAB-MMAE is a cleavable drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). The linker comprises Cys-MC-VC-PAB, facilitating selective release of the potent tubulin inhibitor Monomethyl auristatin E (MMAE) upon internalization. This compound enhances the efficacy of ADCs by delivering chemotherapeutic payloads directly to target cells, thereby improving therapeutic outcomes in cancer research applications.
Cys-MC-VC-PAB-MMAE 3051855-32-1 Drug-Linker Conjugates for ADC
Grouped product items
Size Price Stock Qty
5mg
$245.00
In stock
10mg
$410.00
In stock
25mg
$775.00
In stock
50mg
$1,230.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCys-MC-VC-PAB-MMAE is a cleavable drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). The linker comprises Cys-MC-VC-PAB, facilitating selective release of the potent tubulin inhibitor Monomethyl auristatin E (MMAE) upon internalization. This compound enhances the efficacy of ADCs by delivering chemotherapeutic payloads directly to target cells, thereby improving therapeutic outcomes in cancer research applications.
Product Information
Catalog NumA41424
FormulaC71H112N12O17S
Molecular Weight1437.78
CAS Number3051855-32-1
SMILESO[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C(CC4=O)SC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC