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DBA-DM4

Catalog No.: A41515
Drug-Linker Conjugates for ADC
DBA-DM4 is a drug-linker conjugate designed for use in antibody-drug conjugate (ADC) applications. It combines the potent tubulin inhibitor DM1 with the SPDP linker to facilitate targeted delivery of cytotoxic agents to cancer cells. DBA-DM4 is utilized in research aimed at enhancing the efficacy and selectivity of therapeutic antibodies in oncology, making it a valuable tool for the development of novel cancer treatments.
DBA-DM4 905449-84-5 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDBA-DM4 is a drug-linker conjugate designed for use in antibody-drug conjugate (ADC) applications. It combines the potent tubulin inhibitor DM1 with the SPDP linker to facilitate targeted delivery of cytotoxic agents to cancer cells. DBA-DM4 is utilized in research aimed at enhancing the efficacy and selectivity of therapeutic antibodies in oncology, making it a valuable tool for the development of novel cancer treatments.
Product Information
Catalog NumA41515
FormulaC42H60ClN3O12S2
Molecular Weight898.52
CAS Number905449-84-5
SMILESC[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC