DDR1-IN-5 is a selective inhibitor of Discoidin Domain Receptor 1 (DDR1), demonstrating an IC50 of 7.36 nM. It effectively inhibits the auto-phosphorylation of DDR1b at Y513, with an IC50 of 4.1 nM. DDR1-IN-5 exhibits anti-cancer activity, making it a valuable tool for cancer research. Additionally, this compound features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition for further biochemical applications.
DDR1-IN-5 is a selective inhibitor of Discoidin Domain Receptor 1 (DDR1), demonstrating an IC50 of 7.36 nM. It effectively inhibits the auto-phosphorylation of DDR1b at Y513, with an IC50 of 4.1 nM. DDR1-IN-5 exhibits anti-cancer activity, making it a valuable tool for cancer research. Additionally, this compound features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition for further biochemical applications.
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