Fig. 1 · Structure
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DDR1-IN-5
DDR1 Inhibitor
DDR1-IN-5 is a selective inhibitor of Discoidin Domain Receptor 1 (DDR1), demonstrating an IC50 of 7.36 nM. It effectively inhibits the auto-phosphorylation of DDR1b at Y513, with an IC50 of 4.1 nM. DDR1-IN-5 exhibits anti-cancer activity, making it a valuable tool for cancer research. Additionally, this compound features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition for further biochemical applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2416022-90-5 |
| Applications | DDR1 Inhibitor |
| Formula | C22H13F3N6O |
| Molecular Weight | 434.37 |
| SMILES | CC1=C(C#CC2=CN=C3N2N=CC=C3)C4=C(C=C1)C(NC5=CN=CC(C(F)(F)F)=C5)=NO4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.