DDR1-IN-6 is a selective inhibitor of Discoidin Domain Receptor 1 (DDR1), exhibiting an IC50 of 9.72 nM. This compound effectively inhibits auto-phosphorylation at the Y513 site of DDR1b, also with an IC50 of 9.7 nM, demonstrating significant anti-cancer activity. Additionally, DDR1-IN-6 serves as a click chemistry reagent due to its alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, facilitating diverse research applications in chemical biology and drug discovery.
DDR1-IN-6 is a selective inhibitor of Discoidin Domain Receptor 1 (DDR1), exhibiting an IC50 of 9.72 nM. This compound effectively inhibits auto-phosphorylation at the Y513 site of DDR1b, also with an IC50 of 9.7 nM, demonstrating significant anti-cancer activity. Additionally, DDR1-IN-6 serves as a click chemistry reagent due to its alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, facilitating diverse research applications in chemical biology and drug discovery.
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