Fig. 1 · Structure
Documents & Downloads
DDR1-IN-6
DDR1 Inhibitor
DDR1-IN-6 is a selective inhibitor of Discoidin Domain Receptor 1 (DDR1), exhibiting an IC50 of 9.72 nM. This compound effectively inhibits auto-phosphorylation at the Y513 site of DDR1b, also with an IC50 of 9.7 nM, demonstrating significant anti-cancer activity. Additionally, DDR1-IN-6 serves as a click chemistry reagent due to its alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, facilitating diverse research applications in chemical biology and drug discovery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2416021-47-9 |
| Applications | DDR1 Inhibitor |
| Formula | C23H14F3N5O |
| Molecular Weight | 433.39 |
| SMILES | FC(C1=CC(NC2=NOC3=C2C=CC(C)=C3C#CC4=CN=C5C=CC=NN54)=CC=C1)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.