Debio-1347 (CH5183284)

Catalog No.: A14415

FGFR1/2/3 inhibitor

Debio-1347 (CH5183284) Chemical Structure

CAS NO. 1265229-25-1

Debio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$190.00
25 mg
$330.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Debio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity.
Targets
FGFR2 FGFR1 FGFR3 FGFR4
7.6 nM9.3 nM22 nM290 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.06 mL 140.3 mL 280.6 mL
0.5 mM 5.61 mL 28.06 mL 56.12 mL
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14415
Actions Inhibitor
M. Wt 356.38
Formula C20H16N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1265229-25-1
Synonyms Debio 1347, Debio1347, CH5183284, CH 5183284, CH-5183284, FF-284, FF284, FF 284
SMILES CC1=NC2=C(N1)C=C(C=C2)N3C(=C(C=N3)C(=O)C4=CC5=CC=CC=C5N4)N

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