Debio-1347 (CH5183284)

Name: Debio-1347 (CH5183284)
Brand: Adooq Bioscience
SKU: A14415
Rating: 100 (268 reviews)

Catalog No.: A14415

FGFR1/2/3 inhibitor

Debio-1347 (CH5183284) Chemical Structure

CAS NO. 1265229-25-1

Debio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity.

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$85.00
25 mg	$150.00
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Biological Activity

Debio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity.

Targets

FGFR2	FGFR1	FGFR3	FGFR4
7.6 nM	9.3 nM	22 nM	290 nM

Solubility *

In vitro	DMSO	70 mg/mL (196.41 mM)
	Water	Insoluble
	Ethanol	Warmed: 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.06 mL	140.3 mL	280.6 mL
0.5 mM	5.61 mL	28.06 mL	56.12 mL
1 mM	2.81 mL	14.03 mL	28.06 mL
5 mM	0.56 mL	2.81 mL	5.61 mL

*The above data is based on the productmolecular weight 356.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A14415
Actions	Inhibitor
CAS No.	1265229-25-1
Formula	C20H16N6O
M. Wt	356.38
Purity	>98%
Synonyms	Debio 1347, Debio1347, CH5183284, CH 5183284, CH-5183284, FF-284, FF284, FF 284
SMILES	CC1=NC2=C(N1)C=C(C=C2)N3C(=C(C=N3)C(=O)C4=CC5=CC=CC=C5N4)N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.