Derazantinib (ARQ-087)
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | Derazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT. | ||
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Targets |
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Catalog Num | A16825 |
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Formula | C29H29FN4O |
Molecular Weight | 468.57 |
CAS Number | 1234356-69-4 |
SMILES | COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1 |
Synonyms | ARQ087, ARQ 087 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 80 mg/mL (170.73 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 21.34 mL | 106.71 mL | 213.42 mL |
0.5 mM | 4.27 mL | 21.34 mL | 42.68 mL |
1 mM | 2.13 mL | 10.67 mL | 21.34 mL |
5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2