Derazantinib (ARQ-087)

Catalog No.: A16825

FGFR inhibitor

Derazantinib (ARQ-087)

Derazantinib (ARQ-087) Chemical Structure

CAS NO. 1234356-69-4

Derazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT.

Availability: In stock

Package Price Qty
2 mg

Regular Price: $190.00

Special Price $152.00

5 mg

Regular Price: $270.00

Special Price $216.00

10 mg

Regular Price: $520.00

Special Price $416.00

50 mg

Regular Price: $1,600.00

Special Price $1,280.00

Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Derazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT.
In vitro DMSO 80 mg/mL (170.73 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.34 mL 106.71 mL 213.42 mL
0.5 mM 4.27 mL 21.34 mL 42.68 mL
1 mM 2.13 mL 10.67 mL 21.34 mL
5 mM 0.43 mL 2.13 mL 4.27 mL

*The above data is based on the productmolecular weight 468.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16825
Actions Inhibitor
CAS No. 1234356-69-4
Formula C29H29FN4O
M. Wt 468.57
Solubility DMSO
Purity >98%
Synonyms ARQ087, ARQ 087
SMILES COCCNCCC1=CC(NC2=NC=C3C[[email protected]@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Derazantinib (ARQ-087) | Derazantinib (ARQ-087) Supplier | purchase | cost | manufacturer | order | distributor | buy 1234356-69-4| 1234356-69-4 Supplier | purchase 1234356-69-4 | 1234356-69-4 cost | 1234356-69-4 manufacturer | order 1234356-69-4 | 1234356-69-4 distributor
Rewards