Dihydrodiol-Ibrutinib (PCI-45227) is a dihydrodiol active metabolite of Ibrutinib, selectively targeting Bruton’s tyrosine kinase (BTK). This compound exhibits inhibitory activity towards BTK that is approximately 15 times lower than that of its parent compound, Ibrutinib. Dihydrodiol-Ibrutinib is utilized in research related to B-cell malignancies and other BTK-mediated pathways, providing insights into the modulation of immune responses and signaling pathways in cancer treatment.
Dihydrodiol-Ibrutinib (PCI-45227) is a dihydrodiol active metabolite of Ibrutinib, selectively targeting Bruton’s tyrosine kinase (BTK). This compound exhibits inhibitory activity towards BTK that is approximately 15 times lower than that of its parent compound, Ibrutinib. Dihydrodiol-Ibrutinib is utilized in research related to B-cell malignancies and other BTK-mediated pathways, providing insights into the modulation of immune responses and signaling pathways in cancer treatment.
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