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DM4-SMCC

Catalog No.: A41383
Drug-Linker Conjugate for ADC
DM4-SMCC is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, utilizing the potent antitubulin agent DM4. This conjugate exhibits significant antitumor activity by employing the non-cleavable SMCC linker to facilitate targeted delivery to cancer cells. DM4-SMCC is essential for research involving ADC development and the exploration of targeted cancer therapies.
DM4-SMCC 1228105-52-9 Drug-Linker Conjugate for ADC
Grouped product items
Size Price Stock Qty
1mg
$200.00
In stock
5mg
$450.00
In stock
10mg
$740.00
In stock
25mg
$1,470.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDM4-SMCC is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, utilizing the potent antitubulin agent DM4. This conjugate exhibits significant antitumor activity by employing the non-cleavable SMCC linker to facilitate targeted delivery to cancer cells. DM4-SMCC is essential for research involving ADC development and the exploration of targeted cancer therapies.
Product Information
Catalog NumA41383
FormulaC54H72ClN5O16S
Molecular Weight1114.69
CAS Number1228105-52-9
SMILESC[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(C)(C)SC(C5)C(N(CC6CCC(C(ON7C(CCC7=O)=O)=O)CC6)C5=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC