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DMEA-PNU-159682 dichloroacetate

Catalog No.: A41098
ADC Cytotoxin
DMEA-PNU-159682 dichloroacetate acts as an antibody-drug conjugate (ADC) cytotoxin, incorporating metabolites of nemorubicin (MMDX) generated from liver microsomes along with the potent cytotoxic agent PNU-159682. This compound exhibits significant biological activity by selectively targeting cancer cells, enabling targeted delivery and enhanced therapeutic efficacy. DMEA-PNU-159682 is applicable in cancer research, specifically in studies focusing on ADC development and the evaluation of cytotoxic mechanisms.
DMEA-PNU-159682 dichloroacetate 1799421-49-0 ADC Cytotoxin
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDMEA-PNU-159682 dichloroacetate acts as an antibody-drug conjugate (ADC) cytotoxin, incorporating metabolites of nemorubicin (MMDX) generated from liver microsomes along with the potent cytotoxic agent PNU-159682. This compound exhibits significant biological activity by selectively targeting cancer cells, enabling targeted delivery and enhanced therapeutic efficacy. DMEA-PNU-159682 is applicable in cancer research, specifically in studies focusing on ADC development and the evaluation of cytotoxic mechanisms.
Product Information
Catalog NumA41098
FormulaC41H49Cl4N3O18
Molecular Weight1013.65
CAS Number1799421-49-0
SMILESOC(C(Cl)Cl)=O.C[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(COC(N(C)CCNC)=O)=O)(O)C4)C(O)=C6C(C(C7=C(OC)C=CC=C7C6=O)=O)=C5O.OC(C(Cl)Cl)=O
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Antibody-drug Conjugates (ADC) > ADC Payload (ADC Cytotoxin)