Dovitinib Dilactic acid (TKI258 Dilactic acid)

Catalog No.: A10198

RTK inhibitor

Dovitinib Dilactic acid (TKI258 Dilactic acid) Chemical Structure

CAS NO. 852433-84-2

Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $60.00

Special Price $48.00

25 mg

Regular Price: $128.00

Special Price $102.40

50 mg

Regular Price: $208.00

Special Price $166.40

100 mg

Regular Price: $380.00

Special Price $304.00

10mM * 1mL in DMSO
$93.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
Targets
Target Value
FLT3IC50: 1nM
c-KitIC50: 2nM
FGFR1IC50: 8nM
VEGFR3/FLT4IC50: 8nM
FGFR3IC50: 9nM
VEGFR1/FLT1IC50: 10nM
VEGFR2/Flk1IC50: 13nM
PDGFRβIC50: 27nM
CSF-1R/c-FmsIC50: 36nM
PDGFRαIC50: 210nM
Insulin ReceptorIC50: 2μM
EGFRIC50: 2μM
c-MetIC50: >3μM
EphA2IC50: 4μM
Tie-2IC50: 4μM
IGF-1RIC50: >10μM
HER2IC50: >10μM
In vitro (25°C) DMSO 90 mg/mL (157.18 mM)
Water 70 mg/mL (122.25 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.46 mL 87.32 mL 174.64 mL
0.5 mM 3.49 mL 17.46 mL 34.93 mL
1 mM 1.75 mL 8.73 mL 17.46 mL
5 mM 0.35 mL 1.75 mL 3.49 mL

*The above data is based on the productmolecular weight 572.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10198
Actions Inhibitor
M. Wt 572.6
Formula C21H21FN6O.2C3H6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 852433-84-2
Synonyms CHIR-258, TKI258
SMILES CC(C(=O)O)O.CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3

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