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$0.00 Biological Activity
Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
Targets
| Target | Value |
|---|---|
| FLT3 | IC50: 1nM |
| c-Kit | IC50: 2nM |
| FGFR1 | IC50: 8nM |
| VEGFR3/FLT4 | IC50: 8nM |
| FGFR3 | IC50: 9nM |
| VEGFR1/FLT1 | IC50: 10nM |
| VEGFR2/Flk1 | IC50: 13nM |
| PDGFRβ | IC50: 27nM |
| CSF-1R/c-Fms | IC50: 36nM |
| PDGFRα | IC50: 210nM |
| Insulin Receptor | IC50: 2μM |
| EGFR | IC50: 2μM |
| c-Met | IC50: >3μM |
| EphA2 | IC50: 4μM |
| Tie-2 | IC50: 4μM |
| IGF-1R | IC50: >10μM |
| HER2 | IC50: >10μM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.46 mL | 87.32 mL | 174.64 mL |
| 0.5 mM | 3.49 mL | 17.46 mL | 34.93 mL |
| 1 mM | 1.75 mL | 8.73 mL | 17.46 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.49 mL |
*The above data is based on the productmolecular weight 572.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10198 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 852433-84-2 |
| Formula | C21H21FN6O.2C3H6O3 |
| M. Wt | 572.6 |
| Purity | >98% |
| Synonyms | CHIR-258, TKI258 |
| SMILES | CC(C(=O)O)O.CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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