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Biological Activity
Dovitinib(CHIR-258; TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) with an IC50 of 5 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.72 mL | 103.62 mL | 207.25 mL |
| 0.5 mM | 4.14 mL | 20.72 mL | 41.45 mL |
| 1 mM | 2.07 mL | 10.36 mL | 20.72 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
*The above data is based on the productmolecular weight 482.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21851 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 692737-80-7 |
| Formula | C24H27FN6O4 |
| M. Wt | 482.51 |
| Purity | >98% |
| Synonyms | CHIR-258 lactate, CHIR258, CHIR 258; TKI-258 lactate, TKI258, TKI 258 |
| SMILES | O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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