Doxorubicin-SMCC

Catalog No.: A41340
Drug-Linker Conjugates for ADC
Doxorubicin-SMCC is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs), featuring a non-cleavable linker and the anthracycline antibiotic Doxorubicin. Doxorubicin targets DNA topoisomerase II, interrupting DNA replication and transcription processes, which leads to cell death in rapidly dividing cancer cells. This reagent is valuable for research applications focused on targeted cancer therapies and the development of innovative drug delivery systems.
Grouped product items
Size Price Stock Qty
5mg
$125.00
In stock
10mg
$210.00
In stock
25mg
$380.00
In stock
50mg
$695.00
In stock
100mg
$1,160.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDoxorubicin-SMCC is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs), featuring a non-cleavable linker and the anthracycline antibiotic Doxorubicin. Doxorubicin targets DNA topoisomerase II, interrupting DNA replication and transcription processes, which leads to cell death in rapidly dividing cancer cells. This reagent is valuable for research applications focused on targeted cancer therapies and the development of innovative drug delivery systems.
Product Information
Catalog NumA41340
FormulaC39H42N2O14
Molecular Weight762.76
CAS Number400647-59-8
SMILESC[C@@H]1O[C@H](C[C@@H]([C@@H]1O)NC(C2CCC(CC2)CN3C(C=CC3=O)=O)=O)O[C@H]4C[C@](O)(C(CO)=O)CC5=C(O)C(C(C6=C7C(OC)=CC=C6)=O)=C(C7=O)C(O)=C45
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