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Biological Activity
Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug?Cantibody conjugates (ADCs) .
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.55 mL | 107.77 mL | 215.54 mL |
| 0.5 mM | 4.31 mL | 21.55 mL | 43.11 mL |
| 1 mM | 2.16 mL | 10.78 mL | 21.55 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.31 mL |
*The above data is based on the productmolecular weight 463.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18472 |
|---|---|
| CAS No. | 1116745-06-2 |
| Formula | C26H26ClN3O3 |
| M. Wt | 463.96 |
| Purity | >98% |
| SMILES | O=C(N1C[[email protected]@H](CCl)C2=C1C=C(O)C3=CC=CC=C23)C(N4)=CC5=C4C=CC(OCCN(C)C)=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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