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E-3810

VEGFR/FGFR Inhibitor

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Catalog No. A15073

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
E-3810 5mg A15073-5
€180.50
E-3810 10mg A15073-10
€294.50
E-3810 50mg A15073-50
€741.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively.

E-3810

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Chemical Information

Catalog Num A15073
Actions Inhibitor
M. Wt 443.49
Formula C26H25N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1058137-23-7
Synonyms E 3810, E3810, Lucitanib
SMILES code CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC
Chemical Name 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide

Biological Activity

Description
 E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.74 mL 225.48mL
0.5 mM 4.51 mL 22.55 mL 45.1 mL
1 mM 2.25 mL 11.27 mL 22.55 mL
5 mM 0.45 mL 2.25 mL 4.51 mL

*The above data is based on the productmolecular weight 443.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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