Biological Activity
E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.55 mL | 112.74 mL | 225.48 mL |
0.5 mM | 4.51 mL | 22.55 mL | 45.1 mL |
1 mM | 2.25 mL | 11.27 mL | 22.55 mL |
5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A15073 |
---|---|
Actions | Inhibitor |
CAS No. | 1058137-23-7 |
Formula | C26H25N3O4 |
M. Wt | 443.49 |
Purity | >98% |
Synonyms | E 3810, E3810, Lucitanib |
SMILES | CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Regorafenib (BAY 73-4506)
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an ora…
Vatalanib (PTK787) 2HCl
Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors,…
Buflomedil HCl
Buflomedil is a vasoactive agent used to treat peripheral vascular disease.
NVP-BGJ398 phosphate
NVP-BGJ398 phosphate is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respect…
Tivozanib (AV-951)
Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.
Motesanib Diphosphate (AMG-706)
Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived …
CP-547632
CP-547632 is a novel, potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor
FIIN-3
FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor.
Keywords:buy E-3810 | E-3810 Supplier | purchase | cost | manufacturer | order | distributor | buy 1058137-23-7| 1058137-23-7 Supplier | purchase 1058137-23-7 | 1058137-23-7 cost | 1058137-23-7 manufacturer | order 1058137-23-7 | 1058137-23-7 distributor