E7080 (Lenvatinib)

Name: E7080 (Lenvatinib)
Brand: Adooq Bioscience
SKU: A10340
Rating: 100 (4 reviews)

Catalog No.: A10340

VEGFR Inhibitor

Product Citations (4)

E7080 (Lenvatinib) Chemical Structure

CAS NO. 417716-92-8

E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$70.00
50 mg	$150.00
100 mg	$200.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq E7080 (Lenvatinib)

Keisuke Enomoto, .et al. Synergistic Effects of Lenvatinib (E7080) and MEK Inhibitors against Anaplastic Thyroid Cancer in Preclinical Models, Cancers (Basel), 2021, Feb 18;13(4):862 PMID: 33670725
Koide H, .et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 PMID: 29034773
Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Tomoko Ogawa-Morita, .et al. Validation of a Liquid Chromatography-Tandem Mass Spectrometric Assay for Quantitative Analysis of Lenvatinib in Human Plasma, Int J Anal Chem, 2017, 2017: 2341876 PMID: 28680445

Biological Activity

E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.

Targets

Target	Value
VEGFR2/KDR	IC50: 4.0nM
VEGFR3/FLT4	IC50: 5.2nM
VEGFR1/FLT1	IC50: 22nM
PDGFRβ	IC50: 39nM
FGFR1	IC50: 46nM
PDGFRα	IC50: 51nM
Kit	IC50: 100nM
EphB4	IC50: >10μM
IGF-1R	IC50: >10μM
Insulin Receptor	IC50: >10μM
Src	IC50: >10μM
Akt1	IC50: >10μM
CDK4/CyclinD	IC50: >10μM
PLK1	IC50: >10μM
FAK	IC50: >10μM
PKCα	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 35 mg/mL (81.99 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.42 mL	117.12 mL	234.25 mL
0.5 mM	4.68 mL	23.42 mL	46.85 mL
1 mM	2.34 mL	11.71 mL	23.42 mL
5 mM	0.47 mL	2.34 mL	4.68 mL

*The above data is based on the productmolecular weight 426.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10340
Actions	Inhibitor
CAS No.	417716-92-8
Formula	C21H19ClN4O4
M. Wt	426.9
Purity	>98%
Synonyms	E-7080
SMILES	COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.