E7080 (Lenvatinib)

Catalog No.: A10340

VEGFR Inhibitor

E7080 (Lenvatinib)

E7080 (Lenvatinib) Chemical Structure

CAS NO. 417716-92-8

E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $50.00

Special Price $40.00

10 mg

Regular Price: $70.00

Special Price $56.00

50 mg

Regular Price: $150.00

Special Price $120.00

100 mg

Regular Price: $250.00

Special Price $200.00

10mM * 1mL in DMSO
$55.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
Targets
Target Value
VEGFR2/KDRIC50: 4.0nM
VEGFR3/FLT4IC50: 5.2nM
VEGFR1/FLT1IC50: 22nM
PDGFRβIC50: 39nM
FGFR1IC50: 46nM
PDGFRαIC50: 51nM
KitIC50: 100nM
EphB4IC50: >10μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
SrcIC50: >10μM
Akt1IC50: >10μM
CDK4/CyclinDIC50: >10μM
PLK1IC50: >10μM
FAKIC50: >10μM
PKCαIC50: >10μM
In vitro (25°C) DMSO 40 mg/mL (93.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.42 mL 117.12 mL 234.25 mL
0.5 mM 4.68 mL 23.42 mL 46.85 mL
1 mM 2.34 mL 11.71 mL 23.42 mL
5 mM 0.47 mL 2.34 mL 4.68 mL

*The above data is based on the productmolecular weight 426.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10340
Actions Inhibitor
M. Wt 426.9
Formula C21H19ClN4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 417716-92-8
Synonyms E-7080
SMILES COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl

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