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Biological Activity
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.08 mL | 45.4 mL | 90.8 mL |
| 0.5 mM | 1.82 mL | 9.08 mL | 18.16 mL |
| 1 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 5 mM | 0.18 mL | 0.91 mL | 1.82 mL |
*The above data is based on the productmolecular weight 1101.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14021 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 512-64-1 |
| Formula | C51H64N12O12S2 |
| M. Wt | 1101.3 |
| Purity | >98% |
| Synonyms | Antibiotic A 654I, NSC 526417, Quinomycin A, SK 302B, NSC 13502 |
| SMILES | CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OC[[email protected]](C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)[[email protected]@H](COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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