EMD-1214063

Catalog No.: A11257

c-Met Inhibitor

EMD-1214063

EMD-1214063 Chemical Structure

CAS NO. 1100598-32-0

EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. It binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $110.00

Special Price $99.00

10 mg

Regular Price: $200.00

Special Price $180.00

50 mg

Regular Price: $400.00

Special Price $360.00

100 mg

Regular Price: $700.00

Special Price $630.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. It binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.
Targets
Target Value
c-MetIC50: 4nM
IRAK4IC50: 615nM
TrkAIC50: 1.017μM
AxlIC50: 1.566μM
IRAK1IC50: 2.037μM
MerIC50: 2.272μM
TrkBIC50: 5.716μM
RONIC50: >10μM
In vitro DMSO 5 mg/mL heating (10.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.3 mL 101.5 mL 203 mL
0.5 mM 4.06 mL 20.3 mL 40.6 mL
1 mM 2.03 mL 10.15 mL 20.3 mL
5 mM 0.41 mL 2.03 mL 4.06 mL

*The above data is based on the productmolecular weight 492.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11257
Actions Inhibitor
M. Wt 492.6
Formula C29H28N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1100598-32-0
Synonyms EMD1214063
SMILES CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC(=CC=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N

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