Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc

Catalog No.: A41162
ADC Cytotoxin
Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc is an antibody-drug conjugate (ADC) cytotoxin designed for targeted cancer therapy. This compound exerts its cytotoxic effects primarily through the inhibition of topoisomerase I, leading to DNA damage and subsequent cell death in malignant cells. It is utilized in research for the development of innovative ADCs, optimizing delivery mechanisms for enhanced tumor selectivity and therapeutic efficacy.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionExatecan-2-(aminomethoxy)acetamide-Gly-Fmoc is an antibody-drug conjugate (ADC) cytotoxin designed for targeted cancer therapy. This compound exerts its cytotoxic effects primarily through the inhibition of topoisomerase I, leading to DNA damage and subsequent cell death in malignant cells. It is utilized in research for the development of innovative ADCs, optimizing delivery mechanisms for enhanced tumor selectivity and therapeutic efficacy.
Product Information
Catalog NumA41162
FormulaC44H40FN5O9
Molecular Weight801.81
CAS Number1599440-09-1
SMILESO=C(OCC1C2=CC=CC=C2C3=CC=CC=C31)NCC(NCOCC(N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95)=O)=O
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