FG-2216

Catalog No.: A15530

HIF-prolyl hydroxylase inhibitor

FG-2216

FG-2216 Chemical Structure

CAS NO. 223387-75-5

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo,

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$90.00
25 mg
$180.00
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Biological Activity

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo,
Targets
PHD2
3.9 μM
In vitro (25°C) DMSO 48 mg/mL (171.02 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40% PEG 300+2% Twenn 80+ddH2O 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.63 mL 178.15 mL 356.3 mL
0.5 mM 7.13 mL 35.63 mL 71.26 mL
1 mM 3.56 mL 17.82 mL 35.63 mL
5 mM 0.71 mL 3.56 mL 7.13 mL

*The above data is based on the productmolecular weight 280.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15530
Actions Inhibitor
CAS No. 223387-75-5
Formula C12H9ClN2O4
M. Wt 280.66
Purity >98%
Synonyms YM-311
SMILES C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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