FGFR2/3-IN-1 is a selective inhibitor targeting FGFR2 and FGFR3, exhibiting IC50 values of 1 nM and 0.5 nM, respectively. This compound demonstrates over 40-fold selectivity against FGFR1 and FGFR4, as well as across the wider kinome. Additionally, FGFR2/3-IN-1 effectively inhibits FGFR3 mutants V555L and V555M, with IC50s of 2.7 nM and 6.1 nM, respectively. It is primarily used in research applications focused on cancer biology and receptor signaling pathways.
FGFR2/3-IN-1 is a selective inhibitor targeting FGFR2 and FGFR3, exhibiting IC50 values of 1 nM and 0.5 nM, respectively. This compound demonstrates over 40-fold selectivity against FGFR1 and FGFR4, as well as across the wider kinome. Additionally, FGFR2/3-IN-1 effectively inhibits FGFR3 mutants V555L and V555M, with IC50s of 2.7 nM and 6.1 nM, respectively. It is primarily used in research applications focused on cancer biology and receptor signaling pathways.
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