FLT3-IN-11 is a potent and selective inhibitor of FLT3 kinase, exhibiting IC50 values of 7.22 nM and 4.95 nM for wild-type FLT3 and the FLT3-D835Y mutant, respectively. This compound demonstrates over 1000-fold selectivity for FLT3 compared to c-KIT. FLT3-IN-11 shows significant anti-acute myeloid leukemia (AML) activity, with an IC50 of 3.2 nM in MV4-11 cell assays, making it a valuable tool for research in AML therapeutics.
FLT3-IN-11 is a potent and selective inhibitor of FLT3 kinase, exhibiting IC50 values of 7.22 nM and 4.95 nM for wild-type FLT3 and the FLT3-D835Y mutant, respectively. This compound demonstrates over 1000-fold selectivity for FLT3 compared to c-KIT. FLT3-IN-11 shows significant anti-acute myeloid leukemia (AML) activity, with an IC50 of 3.2 nM in MV4-11 cell assays, making it a valuable tool for research in AML therapeutics.
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