FLT3-IN-14 is a potent inhibitor of the FLT3 receptor, exhibiting IC50 values of 5.6 nM for wild-type FLT3 and 1.4 nM for the FLT3-ITD mutant. This compound effectively reduces the phosphorylation of FLT3 at Y591, leading to cell cycle arrest in the G1 phase and subsequent induction of apoptosis. In preclinical studies, FLT3-IN-14 has demonstrated significant efficacy in reducing tumor growth within MV4-11 xenograft mouse models, highlighting its potential for therapeutic applications in FLT3-related malignancies.
FLT3-IN-14 is a potent inhibitor of the FLT3 receptor, exhibiting IC50 values of 5.6 nM for wild-type FLT3 and 1.4 nM for the FLT3-ITD mutant. This compound effectively reduces the phosphorylation of FLT3 at Y591, leading to cell cycle arrest in the G1 phase and subsequent induction of apoptosis. In preclinical studies, FLT3-IN-14 has demonstrated significant efficacy in reducing tumor growth within MV4-11 xenograft mouse models, highlighting its potential for therapeutic applications in FLT3-related malignancies.
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